ea0015s33 | Evolving endocrine targets for C-type natriuretic peptide (CNP) | SFEBES2008
Fowkes Rob
, Jonas Kim
, Thompson Iain
, Chand Annisa
, Ansorge Olaf
, Wass John
Despite being identified almost two decades ago, the biological roles for C-type natriuretic peptide (CNP) have remained poorly elucidated. Both CNP and GC-B are highly conserved from flies and fish to humans. Recent investigations involving the disruption of the CNP gene (Nppc) or that of its GC-B receptor (Npr2) implicate a role for CNP and GC-B in bone formation and growth. Intriguingly, CNP and GC-B knock-out mouse models also exhibited pituitary growth hormone deficiency....